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International Journal of Biomedical Research & Health Sciences

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Formulation and Evaluation of Essential Oil-Based (Tanacetum Annuum) Nanoparticles for Rheumatoid Arthritis

Abstract

Rheumatic arthritis constitutes severe autoimmune joint related long term inflammatory disorder that mainly affects the hand and feet joints. Approximately 1% population of the adults are suffering from rheumatic arthritis disorder. The symptoms associated with rheumatic arthritis include pain, discomfort, stiffness and swelling of different types of joints. Essential oils are naturally occurring volatile organic compounds that can be obtained from an aromatic plant. Most of them seem to have biological or medicinal behaviours that can function alone or in combination. So, they can be used in the pharmaceutical industry as a therapeutic agent. The interest in the essential oil is increasing day by day due to its vast efficacy for the treatment of several human diseases and they can possess anti-inflammatory and anti-arthritic activity. However, they are poor in water solubility, unstable in environmental conditions and most of them are impermeable across the biological membrane. Presently microemulsions are used to overcome these limitations and its pharmaceutical application. Microemulsion is thermodynamically stable in nature. Due to volatile nature of essential oil microemulsion seemed to be a better candidate for entrapment of oil. Microemulsion has advantages like it can prevent fragile compounds against enzymatic degradation, control release, improve solubilization and thus it can also improve the bioavailability of poorly bioavailable substances. The purpose of this research is to increase the solubilization, bioavailability and permeability of the essential oil for treating the disease like Rheumatic arthritis

Keywords: Dirac’s elegant, Relativistic, Newtonian point